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Persistence of alveolar fibroblast-derived ADAMTS4+ cells in a preclinical model of delayed pulmonary fibrosis resolution
May 8, 2026
Idiopathic pulmonary fibrosis is the most common and aggressive form of interstitial lung disease. Despite […]
TNF superfamily member 14 drives post-influenza depletion of alveolar macrophages, enabling secondary pneumococcal pneumonia.
November 18, 2025
Secondary bacterial infection, often caused by Streptococcus pneumoniae, is one of the most frequent and […]
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
May 2, 2025
Resolution of lung injuries is vital to maintain gas exchange, but there is an increased […]
Evidence for a lipofibroblast-to- Cthrc1 + myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice
October 10, 2024
Background: Fibrosis is often associated with aberrant repair mechanisms that ultimately lead […]
Gut microbiota-derived butyrate selectively interferes with growth of carbapenem-resistant Escherichia coli based on their resistance mechanism
September 18, 2024
We investigated consequences of resistance acquisition in Escherichia coli clinical isolates during anaerobic (continuous culture) […]
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
April 19, 2024
Background: The precise origin of newly formed ACTA2+ (alpha smooth muscle actin-positive) […]
Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia
January 2, 2024
Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to […]
Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting
October 2, 2023
Alveolar macrophages (AMs) are the sentinel cells of the alveolar space, maintaining homeostasis, fending off […]
The lung mesenchyme in development, regeneration, and fibrosis
July 17, 2023
Mesenchymal cells are uniquely located at the interface between the epithelial lining and the stroma, […]